new drug regimen for tuberculosis

New drug targets for Mycobacterium tuberculosis.

In spite of the availability of effective chemotherapy and Bacille-Calmette-Guerin (BCG) vaccine, tuberculosis remains a leading infectious killer world-wide. Many factors such as, human immunodeficiency virus (HIV) co-infection, drug resistance, lack of patient compliance with chemotherapy, delay in diagnosis, variable efficacy of BCG vaccine and various other factors contribute to the mortali...

Drug-resistant tuberculosis: new challenges.

Quantitative Drug-Susceptibility in Patients Treated for Multidrug-Resistant Tuberculosis in Bangladesh: Implications for Regimen Choice

BACKGROUND Multidrug-resistant tuberculosis (MDR-TB) treatment in Bangladesh is empiric or based on qualitative drug-susceptibility testing (DST) by comparative growth in culture media with and without a single drug concentration. METHODS Adult patients were enrolled throughout Bangladesh during the period of 2011-2013 at MDR-TB treatment initiation. Quantitative DST by minimum inhibitory con...

Additional Drug Resistance Patterns among Multidrug-Resistant Tuberculosis Patients in Korea: Implications for Regimen Design

Detailed information on additional drug resistance patterns of multidrug-resistant tuberculosis (MDR-TB) is essential to build an effective treatment regimen; however, such data are scarce in Korea. We retrospectively analyzed the results of phenotypic drug susceptibility testing (DST) of culture confirmed-TB patients from January 2010 to December 2014 in 7 university hospitals in Korea. MDR-TB...

Proposal for a standardised treatment regimen to manage pre- and extensively drug-resistant tuberculosis cases.

Affiliations: Pneumology Department, Hospital General de Gran Canaria “Dr. Negrin”, Las Palmas de GC, Spain. Tuberculosis Division, International Union against Tuberculosis and Lung Disease (The Union), Paris, France. MDR-TB Division, Damien Foundation, Brussels, Belgium. The Global Fund to Fight Aids, Tuberculosis and Malaria, Geneva, Switzerland. Maugeri Care and Research Institute, Tradate, ...

Drug-Resistant Mycobacterium tuberculosis among New Tuberculosis Patients, Yangon, Myanmar

274 Emerging Infectious Diseases • Vol. 9, No. 2, February 2003 and no reports of disease transmission were received from any other recipients of organs from this donor. In addition, the patient had no history of receiving infusions of holistic or alternative medicines. The organism was initially detected in the aerobic Bact/Alert blood culture system (bioMérieux, Inc., Durham, NC) after 72 h i...